Efek Pemberian Asam Alfa Lipoat pada Histopatologi Aorta Torakalis Tikus Diabetes Melitus Tipe 2

Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat Rattus novergicus Wistar strain were separated into three groups (n=5), there labelled as control, diabetes (DM), DM + ALA. Type rats induced streptozotocin (50 mg/kg bodyweight) nicotinamide (110 categorized if blood glucose level >250 mg/dl. Alpha was administered via intraperitoneal (60 mg/kg/day) conducted for 3 weeks. The measured parameter atherosclerosis lesion score. Results showed that no significant difference in scores between all designed (p=0,071). It can be concluded ALA did not have a